Thionyl Chloride → Quinazoline

HRID 2037195

반응식

HRID 2037195 반응식
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][C:2]1=O.O=S(Cl)Cl>CN(C=O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][CH:2]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 3443811,2-Dihydroquinazolin-2-one

생성물 1

HCID 9210Quinazoline

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

Quinazolone Z.8 (817 mg, 3.36 mmol) is combined with SOCl2 (20 mL) and DMF (0.05 mL) and heated to 80° C. for 2 h. The solvent is removed and quinazoline D*.3 (879 mg, 100%) is obtained.

후처리

  1. customThe solvent is removed

출처 및 근거

ORD 기록
ord-5bf1266c1c394ca5b57cf6833a86d9fc
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575203B2

연결된 노트

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