Phosphorus oxychloride → 2-Chloro-4-phenylthiazole

반응식

[C:1]1([C:7]2[NH:8][C:9](=O)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:15]>>[Cl:15][C:9]1[S:10][CH:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 6989032-Hydroxy-4-phenylthiazole

생성물 1

HCID 27613592-Chloro-4-phenylthiazole수율 57%

실험 절차

4-Phenyl-3H-thiazol-2-one (5 g, 28.2 mmol) was dissolved in POCl3 (30 mL), and the mixture was refluxed overnight. The mixture was concentrated in vacuum, and the residue was purified by column chromatography to give 2-chloro-4-phenylthiazole (3.1 g, 57%).

후처리

temperaturethe mixture was refluxed overnight
concentrationThe mixture was concentrated in vacuum
customthe residue was purified by column chromatography

출처 및 근거

ORD 기록: ord-1cc5365b28cf420f811c50c15b2f1e98
출처 데이터셋: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08575156B2

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