Octanal → 2-Benzoyl-dec-2-enoic acid ethyl ester

HRID 2038581

반응식

HRID 2038581 반응식
N1CCCCC1.[CH:7](=O)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[C:16]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(OC)(C)(C)C>[CH2:28]([O:27][C:25](=[O:26])[C:24]([C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[CH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH3:29]

참가 물질

5

반응물 3

HCID 454OctanalHCID 7170Ethyl benzoylacetateHCID 8082Piperidine

생성물 1

HCID 688401452-Benzoyl-dec-2-enoic acid ethyl ester

시약·촉매·용매 1

HCID 15413tert-Butyl methyl ether용매

실험 절차

Piperidine (0.10 ml, 0.5 mol %) is added to a mixture of octanal (25.6 g, 0.20 mol) and ethyl benzoylacetate (38.4 g, 0.20 mol) at 5° C. The resulting solution is warmed to room temperature and stirred for 24 h, during which a fine emulsion is formed. The mixture is diluted with methyl t-butyl ether and the organic layer washed with 2 N aq. HCl-solution, water and brine, then dried over MgSO4.

후처리

  1. customis formed
  2. washthe organic layer washed with 2 N aq. HCl-solution, water and brine
  3. dry with materialdried over MgSO4

출처 및 근거

ORD 기록
ord-8a16591f13ae4bc8ba16a760b02e248a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575386B2

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