Sodium cyanoborohydride → 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(2-oxo-piperidin-1-ylmethyl)-benzamide

HRID 2038650

반응식

HRID 2038650 반응식
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.C([BH3-])#N.[Na+].[F:15][C:16]1[C:17]([NH:32][C:33]2[CH:38]=[CH:37][C:36]([I:39])=[CH:35][C:34]=2[F:40])=[C:18]([CH:26]=[C:27]([CH:30]=O)[C:28]=1[F:29])[C:19]([NH:21][O:22][CH2:23][CH2:24][OH:25])=[O:20]>O1CCCC1>[F:15][C:16]1[C:17]([NH:32][C:33]2[CH:38]=[CH:37][C:36]([I:39])=[CH:35][C:34]=2[F:40])=[C:18]([CH:26]=[C:27]([CH2:30][N:2]2[CH2:3][CH2:4][CH2:5][CH2:6][C:7]2=[O:9])[C:28]=1[F:29])[C:19]([NH:21][O:22][CH2:23][CH2:24][OH:25])=[O:20]

참가 물질

5

반응물 3

HCID 5003444Sodium cyanoborohydrideHCID 13672034Methyl 5-aminopentanoate hydrochlorideHCID 231323883,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide

생성물 1

HCID 115342093,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(2-oxo-piperidin-1-ylmethyl)-benzamide수율 37%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 5-amino-pentanoate hydrochloride {see J. Org. Chem. (1968) 1581} (128 mg, 0.178 mmol) and sodium cyanoborohydride (45 mg, 0.718 mmol) were added to a solution of 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide (115 mg, 0.239 mmol) obtained in Step F of Example 1 in tetrahydrofuran (anhydrous, 4.0 mL). The mixture was stirred at room temperature for 1.5 hours. Then, the reaction vessel was equipped with a reflux condenser, and the mixture was heated at 60° C. for 2 days. After completion of the reaction, the reaction mixture was extracted with ethyl acetate, and the organic layer was washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resultant residue was purified by silica gel flash chromatography (Mega Bond Elut, Varian, 4% methanol/methylene chloride as an eluent) to give 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(2-oxo-piperidin-1-ylmethyl)-benzamide (Compound H-4, 42.7 mg, 37%) as a white solid.

후처리

  1. customThen, the reaction vessel was equipped with a reflux condenser
  2. temperaturethe mixture was heated at 60° C. for 2 days
  3. customAfter completion of the reaction
  4. extractionthe reaction mixture was extracted with ethyl acetate
  5. washthe organic layer was washed sequentially with water and saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customThe resultant residue was purified by silica gel flash chromatography (Mega Bond Elut, Varian, 4% methanol/methylene chloride as an eluent)

출처 및 근거

ORD 기록
ord-017976af8fb549d2a881faee57731d3a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575391B2

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