Hydrochloric Acid → (R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt

HRID 2038751노트

반응식

HRID 2038751 반응식
[Br:1][C:2]1[N:7]=[CH:6][C:5]([C@H:8]([NH:10]S(C(C)(C)C)=O)[CH3:9])=[CH:4][CH:3]=1.[ClH:17].O1CCOCC1.CCOCC>CO>[ClH:17].[Br:1][C:2]1[N:7]=[CH:6][C:5]([C@H:8]([NH2:10])[CH3:9])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 312751,4-DioxaneHCID 889592202-methyl-propane-2-sulfinic acid[(R)-1-(6-bromo-pyridin-3-yl)-ethyl]-amide

생성물 1

HCID 53487712(R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt수율 87%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-methyl-propane-2-sulfinic acid[(R)-1-(6-bromo-pyridin-3-yl)-ethyl]-amide (650 mg, 2.13 mmol) in MeOH (5 mL) was added 4.0M HCl in dioxane (5.32 mL, 21.30 mmol). The clear reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture became cloudy during this time. Ether (20 mL) was added, and the mixture was stirred for 10 min and then filtered, washed with ether (20 mL) to afford (R)-1-(6-bromo-pyridin-3-yl)-ethylamine HCl salt (500 mg, 87%) as a white solid.

후처리

  1. stirringthe mixture was stirred for 10 min
  2. filtrationfiltered
  3. washwashed with ether (20 mL)

출처 및 근거

ORD 기록
ord-65baaa4f989049aaa2c3e6e1cb9a0a31
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575360B2

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