Dichloromethane → 1-[5-(1-Methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropylamine dihydrochloride

HRID 2038773노트

반응식

HRID 2038773 반응식
C(OC(=O)[NH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=3)=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.O1CCOCC1.C(Cl)[Cl:31]>Cl>[ClH:31].[ClH:31].[CH3:22][N:20]1[CH:21]=[C:17]([C:14]2[CH:15]=[CH:16][C:11]([C:8]3([NH2:7])[CH2:10][CH2:9]3)=[N:12][CH:13]=2)[CH:18]=[N:19]1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 312751,4-Dioxane2회HCID 67515892{1-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester

생성물 1

HCID 683794491-[5-(1-Methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropylamine dihydrochloride

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매2회

실험 절차

To a solution of {1-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester (1.1 g, 3.5 mmol) in CH2Cl2 (15 mL), 4.0M HCl in dioxane (4.35 mL, 17.5 mmol) was added. After stirring overnight, more 4.0M HCl in dioxane (4.35 mL, 17.5 mmol) was added to the solution. After another 12 hours, the solution was concentrated in-vacuo to yield 800 mg of the title compound.

후처리

  1. waitAfter another 12 hours
  2. concentrationthe solution was concentrated in-vacuo

출처 및 근거

ORD 기록
ord-6dfe18c96a90465fad0bb0cc843bf65a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575360B2

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