Hydrochloric Acid → (r)-1-(5-Bromo-pyridin-2-yl)-ethylamine dihydrochloride

HRID 2038782노트

반응식

HRID 2038782 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH:10][S@@](C(C)(C)C)=O)[CH3:9])=[N:6][CH:7]=1.[ClH:17].CCOCC>CO>[ClH:17].[ClH:17].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([NH2:10])[CH3:9])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68237516(R)-2-methyl-propane-2-sulfinic acid[(R)-1-(5-bromo-pyridin-2-yl)-ethyl]-amide

생성물 1

HCID 68378980(r)-1-(5-Bromo-pyridin-2-yl)-ethylamine dihydrochloride수율 101%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of (R)-2-methyl-propane-2-sulfinic acid[(R)-1-(5-bromo-pyridin-2-yl)-ethyl]-amide (500 mg, 1.64 mmol) in 5 mL of MeOH was added HCl (4.10 mL, 16.4 mmol, 4M in dioxane). The reaction mixture was stirred at room temperature for 2.5 h, during which time a white precipitate was formed. 20 mL of Et2O was added. After stirring for an additional 20 min, the reaction mixture was filtered, washing with 10 mL of Et2O. 454 mg (99%) of the title compound was isolated as a white solid after drying under high vacuum.

후처리

  1. customwas formed
  2. stirringAfter stirring for an additional 20 min
  3. filtrationthe reaction mixture was filtered
  4. washwashing with 10 mL of Et2O

출처 및 근거

ORD 기록
ord-f4935b4666d0494eb6d8ebe19039638f
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575360B2

반응 노트

불러오는 중…