Water → (R)-5-[(1S,2S)-2-Amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester

HRID 20392

반응식

HRID 20392 반응식
[C:1]([O:5][C:6]([N:8]1[CH:13]([C@@H:14]([OH:28])[C@@H:15]([N+:25]([O-])=O)[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:29][CH2:30][CH3:31])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[BH4-].[Na+].O>CO.[Ni](Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH:13]([C@@H:14]([OH:28])[C@@H:15]([NH2:25])[CH2:16][C:17]2[CH:18]=[C:19]([F:24])[CH:20]=[C:21]([F:23])[CH:22]=2)[CH2:12][O:11][C@@H:10]([O:29][CH2:30][CH3:31])[CH2:9]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

참가 물질

6

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 68564103(R)-5-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-nitropropyl]-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester

생성물 1

HCID 68563667(R)-5-[(1S,2S)-2-Amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester

시약·촉매·용매 2

HCID 24385Nickel Dichloride촉매HCID 887Methanol용매

실험 절차

To a solution of (R)-5-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-nitropropyl]-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester (0.145 g, 0.325 mmol) in methanol (5 mL) at room temperature add nickel (II) chloride (0.063 g, 0.487 mmol) and then sodium borohydride (0.061 g, 1.62 mmol) portionwise. Stir 30 minutes, add water (˜3 mL) and concentrate. Dilute with ethyl acetate and filter through Celite®. Partition the filtrate between ethyl acetate and water. Dry the ethyl acetate layer (magnesium sulfate), filter and concentrate to give the desired compound as a white solid.

후처리

  1. concentrationconcentrate
  2. additionDilute with ethyl acetate
  3. filtrationfilter through Celite®
  4. customPartition the filtrate between ethyl acetate and water
  5. dry with materialDry the ethyl acetate layer (magnesium sulfate)
  6. filtrationfilter
  7. concentrationconcentrate

출처 및 근거

ORD 기록
ord-c6d13efcbadb45c496155abf183d442b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745438B2

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