Triethyl phosphite → Diethyl (4-Bromobenzyl)phosphonate

HRID 2039412노트

반응식

HRID 2039412 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[P:10]([O:17]CC)([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13]>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][P:10](=[O:17])([O:14][CH2:15][CH3:16])[O:11][CH2:12][CH3:13])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 31215Triethyl phosphiteHCID 685274-Bromobenzyl bromide

생성물 1

HCID 11077666Diethyl (4-Bromobenzyl)phosphonate

실험 절차

40.69 g (1 molar equivalent, 163 mmol) of 4-bromobenzyl bromide 1 are heated at 160° C. in 28.3 ml (1 molar equivalent, 163 mmol) of triethyl phosphite until the evolution of gas is complete. The batch is distilled in vacuo, and the residue remaining in the form of an oil 2 (48.87 g, 98%) is employed in the subsequent reaction without further purification.

후처리

  1. distillationThe batch is distilled in vacuo
  2. customis employed in the subsequent reaction without further purification

출처 및 근거

ORD 기록
ord-57803490aa25423897ffcd1a9902dc71
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580395B2

반응 노트

불러오는 중…