Water → HCID 16117743, 화합물

HRID 2039723노트

반응식

HRID 2039723 반응식
Cl.[N:2]1[C:7]2[NH:8][CH:9]=[C:10]([C:11]3[N:16]=[C:15]([C:17]4[CH2:18][CH2:19][NH:20][CH2:21][CH:22]=4)[CH:14]=[CH:13][CH:12]=3)[C:6]=2[CH:5]=[N:4][CH:3]=1.[C:23]([CH2:25][C:26](ON1CCCC1)=[O:27])#[N:24].C(N(C(C)C)CC)(C)C.O>C(O)C>[O:27]=[C:26]([N:20]1[CH2:19][CH:18]=[C:17]([C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:10]3[C:6]4[CH:5]=[N:4][CH:3]=[N:2][C:7]=4[NH:8][CH:9]=3)[N:16]=2)[CH2:22][CH2:21]1)[CH2:25][C:23]#[N:24]

참가 물질

6

반응물 4

HCID 962WaterHCID 81531DiisopropylethylamineHCID 570164291-Pyrrolidinyl 2-cyanoacetateHCID 69513664HCID 69513664, 화합물

생성물 1

HCID 16117743HCID 16117743, 화합물수율 16.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

As shown in FIG. 7—step v, compound 29 (30 mg) and 2-cyano acetic acid, pyrrolidin-1-yl ester (47 mg) were mixed in ethanol (2 mL) and diisopropylethylamine (0.084 mL) was added. After stirring at rt for 12 hours, water (30 mL) was added. Extraction with dichloromethane (3×) and chromatographic purification (SiO2, ethyl acetate) afforded 5.3 mg of 3-oxo-3-[6-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3′,6′-dihydro-2′H-[2,4′]bipyridinyl-1′-yl]-propionitrile (compound 30).

후처리

  1. extractionExtraction
  2. customwith dichloromethane (3×) and chromatographic purification (SiO2, ethyl acetate)

출처 및 근거

ORD 기록
ord-01b70f409264402c960c2992d08ef95a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580802B2

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