Ethanol → 3-Phenylprop-2-ynal oxime

HRID 2040838노트

반응식

HRID 2040838 반응식
[C:1]1([C:7]#[C:8][CH:9]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:12][OH:13].CCO>O>[C:1]1([C:7]#[C:8][CH:9]=[N:12][OH:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 75740PhenylpropynalHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 765430553-Phenylprop-2-ynal oxime수율 100.2%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of phenylpropargylaldehyde (859 mg, 6.6 mmol), hydroxylamine hydrochloride (4.59 g, 66 mmol), EtOH (48 mL) and water (12 mL) was stirred at r.t. for 24 h. The reaction mixture was diluted with H2O, extracted with Et2O-EtOAc, washed with brine and evaporated to dryness in vacuo affording 0.96 g of the title compound (syn:anti 1:1) as a pasty brownish solid.

후처리

  1. extractionextracted with Et2O-EtOAc
  2. washwashed with brine
  3. customevaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-e5b6604bca9d464cafbb0a7fe9a0e4c7
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580962B2

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