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Hydrochloric Acid → 2-(1,4'-Bipiperidin-1'-yl)benzo[d]oxazole-5-carboxylic acid

HRID 2041012
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HRID 2041012 반응식
[N:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13]3[O:14][C:15]4[CH:21]=[CH:20][C:19]([C:22]([O:24]C)=[O:23])=[CH:18][C:16]=4[N:17]=3)[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[K+].CO.Cl>O1CCCC1.O>[N:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:13]3[O:14][C:15]4[CH:21]=[CH:20][C:19]([C:22]([OH:24])=[O:23])=[CH:18][C:16]=4[N:17]=3)[CH2:11][CH2:12]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1
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참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 66905434HCID 66905434, 화합물

생성물 1

HCID 669058032-(1,4'-Bipiperidin-1'-yl)benzo[d]oxazole-5-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매
HCID 8028
Tetrahydrofuran
용매

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온도
40 °C

실험 절차

Methyl 2-(1,4′-bipiperidin-1′-yl)benzo[d]oxazole-5-carboxylate (Example 94, 220 mg, 0.641 mmol) and potassium hydroxide were combined in a mixture of tetrahydrofuran, methanol, and water (9:1:1, 7 mL) and stirred at 40° C. overnight. The mixture was neutralized with concentrated hydrochloric acid, concentrated under reduced pressure, and triturated with chloroform to afford the title compound. MS (ESI+) m/z 330.2 (M+H)+.

후처리

  1. concentrationconcentrated under reduced pressure
  2. customtriturated with chloroform

출처 및 근거

ORD 기록
ord-4ca1837ed2c1422287d98e3f52933036
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08580968B2

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