Ammonia → HCID 57656128, 화합물
반응식
[C:1]([NH:5][C:6](=[O:16])[C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9][C:8]=1[F:15])([CH3:4])([CH3:3])[CH3:2].N>CO.[Ni]>[NH2:14][CH2:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]([NH:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:16])=[C:8]([F:15])[CH:9]=1참가 물질
5
실험 절차
Combine N-tert-butyl-4-cyano-2-fluoro-benzamide (0.6 g, 1.78 mmol), Raney® 3201 nickel (slurry in water, 30 mg), 2N ammonia in methanol (30 mL) and hydrogenate at 50 psi for 1 h. Filter the reaction mixture through a pad of Celite®, concentrate in vacuo and purify by SCX chromatography to obtain the title compound as a colorless oil (0.6 g, 96%).
후처리
- filtrationFilter the reaction mixture through a pad of Celite®
- concentrationconcentrate in vacuo
- custompurify by SCX chromatography
출처 및 근거
- ORD 기록
- ord-082a17889a2a499ca3084bb01233999a
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08580780B2
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