Hydrochloric Acid → 1-(6-Fluoropyridin-2-yl)methanamine--hydrogen chloride (1/2)

HRID 2041203노트

반응식

HRID 2041203 반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[N:4]=1)#[N:2].[ClH:10]>C(O)C.[Pd]>[ClH:10].[ClH:10].[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([F:9])[N:4]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 142963696-Fluoropyridine-2-carbonitrile

생성물 1

HCID 513420701-(6-Fluoropyridin-2-yl)methanamine--hydrogen chloride (1/2)수율 73%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Dissolve 2-cyano-6-fluoropyridine (300 mg, 2.46 mmol) in absolute ethanol (12 mL). Add 10% Pd/C (93 mg) and concentrated HCl (0.614 mL, 7.37 mmol). Hydrogenate at 40 psi overnight. Filter through Celite® and concentrate to give the title compound as a solid (356 mg, 73%). MS (ES+) m/z: 127 (M+H)+.

후처리

  1. customat 40 psi overnight
  2. filtrationFilter through Celite®
  3. concentrationconcentrate

출처 및 근거

ORD 기록
ord-1825c43e1c214f9c8a8d835ab110586a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580780B2

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