Hydrochloric Acid → 3-Aminomethyl-6-cyclohexylmethyl-pyridine

HRID 2041525노트

반응식

HRID 2041525 반응식
Cl.C(OC([NH:9][CH2:10][C:11]1[CH:12]=[N:13][C:14]([CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:15][CH:16]=1)=O)(C)(C)C.CCCCCC>O1CCOCC1.CCOC(C)=O>[NH2:9][CH2:10][C:11]1[CH:12]=[N:13][C:14]([CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:15][CH:16]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 576559013-Tert-butoxycarbonylaminomethyl-6-cyclohexylmethyl-pyridine

생성물 1

HCID 576566033-Aminomethyl-6-cyclohexylmethyl-pyridine수율 97%

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 312751,4-Dioxane용매

실험 절차

Add 4N hydrogen chloride in dioxane (10 mL) to a solution of 3-tert-butoxycarbonylaminomethyl-6-cyclohexylmethyl-pyridine (345 mg, 1.13 mmol) in EtOAc (10 mL) and stir overnight. Concentrate in vacuo, suspend the solid obtained in diethyl ether and add hexane. Filter and wash the solid with hexane. Suspend the solid into dichloromethane, add saturated aqueous NaHCO3 and stir until both phases are clear (15 min). Extract the aqueous phase twice with dichoromethane. Dry the combined organic extracts over MgSO4, filter and concentrate in vacuo to obtain the title compound as an oil (205 mg, 97%) that was used without any further purification. MS (ES+) n7/z: 205 (M+H)+.

후처리

  1. concentrationConcentrate in vacuo
  2. customobtained in diethyl ether
  3. filtrationFilter
  4. washwash the solid with hexane
  5. additionadd saturated aqueous NaHCO3
  6. stirringstir until both phases
  7. custom(15 min)
  8. extractionExtract the aqueous phase twice with dichoromethane
  9. dry with materialDry the combined organic extracts over MgSO4
  10. filtrationfilter
  11. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-681bc10dd7f844428b852803deb0f9f8
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580780B2

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