Hydrochloric Acid → HCID 53409533, 화합물

HRID 2041964노트

반응식

HRID 2041964 반응식
[C:1]([C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[O:7][CH:8]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[ClH:24]>O1CCOCC1>[ClH:24].[C:1]([C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[O:7][CH:8]1[CH2:12][CH2:11][NH:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 59577147HCID 59577147, 화합물

생성물 1

HCID 53409533HCID 53409533, 화합물수율 83%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A stirred solution of tert-butyl 3-(2-tert-butylphenoxy)pyrrolidine-1-carboxylate (0.78 g, 2.44 mmol) and hydrochloric acid (7.0 mL of a 4.0 N solution in dioxane, 28.0 mmol) was reacted at room temperature for 16 h. Then, the reaction mixture was concentrated under reduced pressure. The residue was triturated with ethyl acetate to provide 3-(2-tert-butylphenoxy)pyrrolidine hydrochloride as a colorless solid (0.52 g, 83%).

후처리

  1. concentrationThen, the reaction mixture was concentrated under reduced pressure
  2. customThe residue was triturated with ethyl acetate

출처 및 근거

ORD 기록
ord-f014bae3f44241d68b139b214acb94e5
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586571B2

반응 노트

불러오는 중…