Water → p-((1-Oxoallyl)amino)benzoic acid

HRID 2042752노트

반응식

HRID 2042752 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[C:11](Cl)(=[O:14])[CH:12]=[CH2:13].O>CN(C=O)C.N1C=CC=CC=1>[C:11]([NH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)(=[O:14])[CH:12]=[CH2:13]

참가 물질

6

반응물 3

HCID 962WaterHCID 9784-Aminobenzoic AcidHCID 13140Acryloyl chloride

생성물 1

HCID 84866p-((1-Oxoallyl)amino)benzoic acid수율 94.2%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-aminobenzoic acid (1.40 g, 10 mmol) in DMF (10 mL) and pyridine (0.5 ml) was cooled to 0° C. To this solution was added of acryloyl chloride (0.94 g, 10 mmol) and the resulting mixture was stirred for 3 hours. The mixture was poured into 200 ml of water and the white solid obtained was filtered, washed with water and ether. Drying under high vacuum provided 1.8 g of the desired product which was used in the next step without purification.

후처리

  1. customthe white solid obtained
  2. filtrationwas filtered
  3. washwashed with water and ether
  4. customDrying under high vacuum

출처 및 근거

ORD 기록
ord-110f2d321652468f97d23fe6114139f4
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586600B2

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