Sodium Hydroxide → 3-Nitro-2,4-dimethyl-benzylamine

HRID 2042799노트

반응식

HRID 2042799 반응식
[N+:1]([C:4]1[C:5]([CH3:19])=[C:6]([CH:15]=[CH:16][C:17]=1[CH3:18])[CH2:7][NH:8]C(=O)C(F)(F)F)([O-:3])=[O:2].[OH-].[Na+]>CO>[N+:1]([C:4]1[C:5]([CH3:19])=[C:6]([CH:15]=[CH:16][C:17]=1[CH3:18])[CH2:7][NH2:8])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 56840191N-(3-Nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide

생성물 1

HCID 568399723-Nitro-2,4-dimethyl-benzylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of N-(3-nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide (1.53 g, 5.54 mmol), 4M NaOH-solution (6.9 mL, 28 mmol) and MeOH (30 mL) is refluxed for 2 h. Then the mixture is concentrated, diluted with water and extracted with EtOAc. The organic phase is dried with Na2SO4, filtered and concentrated.

후처리

  1. temperatureis refluxed for 2 h
  2. concentrationThen the mixture is concentrated
  3. additiondiluted with water
  4. extractionextracted with EtOAc
  5. dry with materialThe organic phase is dried with Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6d1baf858ea74d8c8a1442eea1d634b1
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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