HCID 178508979, 화합물 → HCID 178507778, 화합물

HRID 2042826노트

반응식

HRID 2042826 반응식
[NH2:1][C:2]1[C:20]([N+:21]([O-])=O)=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:24][CH2:25][CH:26]([F:28])[F:27])[N:3]=1>[Ni].C1COCC1>[NH2:21][C:20]1[C:2]([NH2:1])=[N:3][C:4]([O:24][CH2:25][CH:26]([F:27])[F:28])=[C:5]([CH:19]=1)[C:6]([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([F:17])([F:16])[F:18])[CH2:11][CH2:10]1)=[O:7]

참가 물질

4

반응물 1

HCID 178508979HCID 178508979, 화합물

생성물 1

HCID 178507778HCID 178507778, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 6-amino-2-(2,2-difluoro-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (250 mg, 0.61 mmol), Ra—Ni (30 mg) and THF (10 mL) is stirred at rt for 2 h under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the filtrate is concentrated.

후처리

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated

출처 및 근거

ORD 기록
ord-493cf41805d64f26ba1c36752b416c0f
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

반응 노트

불러오는 중…