Dimethylformamide → [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

HRID 2043

반응식

HRID 2043 반응식
[Na].[N:2]1([C:13](=[O:14])[C:12]2[NH:11][CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5])[CH3:3].Cl[CH2:16][P:17](=[O:20])(C)[CH3:18].[CH3:21]N(C=O)C>>[CH3:7][N:6]1[C:8]2[N:9]=[CH:10][N:11]([CH3:21])[C:12]=2[C:13](=[O:14])[N:2]([CH2:3][P:17](=[O:20])([CH3:18])[CH3:16])[C:4]1=[O:5]

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 669736033,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt

생성물 1

HCID 19689229[1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

실험 절차

A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.

후처리

  1. filtrationThe solution was filtered
  2. customthe solvent was evaporated
  3. filtrationThe precipitate was filtered off
  4. customdried to constant weight under reduced pressure

출처 및 근거

ORD 기록
ord-3604df54e33345c3b923bde3a99dbbb6
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728686

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