Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Phosphine oxide, (chloromethyl)dimethyl- | HCID 74224 | — |
| 반응물 | 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt | HCID 66973603 | — |
| 생성물 | [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide | HCID 19689229 | — |
반응 단계
A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05728686 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-3604df54e33345c3b923bde3a99dbbb6 |
| 출처 메모 | uspto-grants-1998_03 |