Sodium Hydroxide → HCID 67464828, 화합물
반응식
[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]([CH2:10][C:11]([O:13]CC)=[O:12])[N:4]=1)[CH3:2].[OH-].[Na+]>O1CCCC1.O>[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8][CH3:9])[N:5]([CH2:10][C:11]([OH:13])=[O:12])[N:4]=1)[CH3:2]참가 물질
5
실험 절차
Ethyl 3,5-diethyl-1H-pyrazole-1-acetate (2.79 g, 13.3 mmol) (i.e. the product of Example 15, Step B) in tetrahydrofuran (10 mL) was treated with sodium hydroxide (1.0 g) in water (7.5 mL) The reaction mixture was then stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and washed with diethyl ether. The resulting aqueous layer was acidified with concentrated hydrochloric acid to give a white precipitate. The precipitate was filtered and dried in air to give 690 mg of the title compound.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- washwashed with diethyl ether
- customto give a white precipitate
- filtrationThe precipitate was filtered
- customdried in air
출처 및 근거
- ORD 기록
- ord-bfa68867fba0460c8472e74c1bf36b72
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08586611B2
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