Sodium Hydroxide → 922516-30-1

HRID 2043755노트

반응식

HRID 2043755 반응식
[CH2:1]([C:3]1[N:7]([CH2:8][C:9]([O:11]CC)=[O:10])[N:6]=[C:5]([C:14]([F:17])([F:16])[F:15])[CH:4]=1)[CH3:2].[OH-].[Na+]>O1CCCC1.O>[CH2:1]([C:3]1[N:7]([CH2:8][C:9]([OH:11])=[O:10])[N:6]=[C:5]([C:14]([F:17])([F:16])[F:15])[CH:4]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 67464244ethyl 5-ethyl-3-(trifluoromethyl)-1H-pyrazole-1-acetate2회

생성물 1

HCID 67464323922516-30-1수율 41.4%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl 5-ethyl-3-(trifluoromethyl)-1H-pyrazole-1-acetate (1.34 g, 7.5 mmol) (i.e. the product of Example 16, Step B) in tetrahydrofuran (5 mL) was treated with sodium hydroxide (0.5 g) in water (3.5 mL). The reaction mixture was then stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and washed with diethyl ether. The resulting aqueous layer was acidified with concentrated hydrochloric acid to give a white precipitate. The precipitate was filtered and dried in air to give 690 mg of the title compound.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washwashed with diethyl ether
  3. customto give a white precipitate
  4. filtrationThe precipitate was filtered
  5. customdried in air

출처 및 근거

ORD 기록
ord-66ab70ac8810414a90e0aa00e94a5bba
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586611B2

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