Hydrochloric Acid → CVPGZGBBLDOWIH-UHFFFAOYSA-N

HRID 2043762노트

반응식

HRID 2043762 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][N:7]([CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[N:6]=1)=[O:4].[ClH:23]>C(OCC)C>[ClH:23].[NH:13]1[CH2:14][CH2:15][CH:10]([N:7]2[CH:8]=[CH:9][C:5]([C:3]([O:2][CH3:1])=[O:4])=[N:6]2)[CH2:11][CH2:12]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 674641231,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate2회

생성물 1

HCID 67461532CVPGZGBBLDOWIH-UHFFFAOYSA-N

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a solution of 1,1-dimethylethyl 4-[3-(methoxycarbonyl)-1H-pyrazol-1-yl]-1-piperidinecarboxylate (300 mg, 0.97 mmol) (i.e. the product of Example 18, Step B) in 5 mL of diethyl ether was added a 2 M solution of hydrogen chloride in ether (4.85 mL, 9.7 mmol), and the reaction mixture was stirred for 5 h at room temperature. The reaction mixture was evaporated in vacuo, the resulting residue was dissolved in methanol and concentrated in vacuo. The residue was dried in high vacuum to give 200 mg of the title compound as a white solid.

후처리

  1. customThe reaction mixture was evaporated in vacuo
  2. dissolutionthe resulting residue was dissolved in methanol
  3. concentrationconcentrated in vacuo
  4. customThe residue was dried in high vacuum

출처 및 근거

ORD 기록
ord-38ab3ed50a94420386ba56960e957749
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586611B2

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