Benzocaine → HCID 67441424, 화합물

HRID 2045291노트

반응식

HRID 2045291 반응식
[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:2].[F:13][C:14]1[CH:15]=[CH:16][C:17]([CH3:22])=[C:18]([CH:21]=1)[CH:19]=O>C(O)C>[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([N:11]=[CH:19][C:18]2[CH:21]=[C:14]([F:13])[CH:15]=[CH:16][C:17]=2[CH3:22])=[CH:7][CH:6]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 2337BenzocaineHCID 27590125-Fluoro-2-methylbenzaldehyde

생성물 1

HCID 67441424HCID 67441424, 화합물수율 70.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-amino-benzoic acid ethyl ester (1.65 g, 10 mmol) and 5-fluoro-2-methyl-benzaldehyde (1.38 g, 10 mmol) in ethanol (10 mL) was heated to reflux for 2 hours. Then the reaction mixture cooled to room temperature. The solvent was removed in vacuo and the residue was washed with ether to afford 4-{[1-(5-fluoro-2-methyl-phenyl)-methylidene]-amino}-benzoic acid ethyl ester (2.0 g, 70%) as a white solid: LC/MS m/e calcd for C17H16FNO2 (M+H)+: 285.3, observed: 286.3.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 2 hours
  3. customThe solvent was removed in vacuo
  4. washthe residue was washed with ether

출처 및 근거

ORD 기록
ord-fe36ea9aa1354dc8ae6b3c0059b2a257
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586747B2

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