홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropylethylamine → 1-t-Butyl 2-methyl (2S,4R)-4-[(2-ethoxy-7-methoxy-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

HRID 2045709
노트
인쇄 미리보기

반응식

HRID 2045709 반응식
F[B-](F)(F)F.[CH2:6]([O+](CC)CC)[CH3:7].[CH3:13][O:14][C:15]1[CH:24]=[C:23]2[C:18]([C:19]([O:26][C@H:27]3[CH2:31][N:30]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C@H:29]([C:39]([O:41][CH3:42])=[O:40])[CH2:28]3)=[CH:20][C:21](=[O:25])[NH:22]2)=[CH:17][C:16]=1[CH:43]=[CH2:44].CCN(C(C)C)C(C)C.C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH2:6]([O:25][C:21]1[CH:20]=[C:19]([O:26][C@H:27]2[CH2:31][N:30]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C@H:29]([C:39]([O:41][CH3:42])=[O:40])[CH2:28]2)[C:18]2[C:23](=[CH:24][C:15]([O:14][CH3:13])=[C:16]([CH:43]=[CH2:44])[CH:17]=2)[N:22]=1)[CH3:7]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 516892Sodium BicarbonateHCID 2723982Triethyloxonium tetrafluoroborateHCID 592799081-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

생성물 1

HCID 580914531-t-Butyl 2-methyl (2S,4R)-4-[(2-ethoxy-7-methoxy-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Triethyloxonium tetrafluoroborate (1.28 g, 6.75 mmol) was added to a solution of the product from step 3 (2.0 g, 4.5 mmol) in DCM (41 mL). DIEA (0.236 mL, 1.35 mmol) was then added after 15 min. After 45 additional min, the reaction mixture was worked up with NaHCO3 and DCM. The organic layer was then dried over MgSO4, and the solvent was removed in vacuo. The crude material was then purified on silica (gradient elution, 10-60% EtOAc/hexanes) to yield the title compound as an oil. LRMS (M+H)+=473.4.

후처리

  1. dry with materialThe organic layer was then dried over MgSO4
  2. customthe solvent was removed in vacuo
  3. customThe crude material was then purified on silica (gradient elution, 10-60% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-2c4a9084f3e0447885ea7b7062f3b5de
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08591878B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트