Hydrochloric Acid → HCID 2959448, 화합물

HRID 2045799노트

반응식

HRID 2045799 반응식
[C:1]([CH:3]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])#[N:2].[ClH:16]>C(O)C.[Pd]>[ClH:16].[NH2:2][CH2:1][CH:3]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 12414061Ethyl 3-cyano-3-phenylpropanoate

생성물 1

HCID 2959448HCID 2959448, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of ethyl 3-cyano-3-phenylpropanoate 2 (9.27 g, 45.6 mmol) in ethanol (70 mL) was added concentrated hydrochloric acid (2.4 mL) followed by 10% palladium on carbon (1.0 g) and the reaction hydrogenated at 80 psi for 18 h. The mixture was filtered through celite and concentrated in vacuo. The residue was triturated in ether and filtered to give 2 (4.97 g in 2 crops, 45%) as a white solid.

후처리

  1. customthe reaction hydrogenated at 80 psi for 18 h
  2. filtrationThe mixture was filtered through celite and
  3. concentrationconcentrated in vacuo
  4. customThe residue was triturated in ether
  5. filtrationfiltered
  6. customto give 2 (4.97 g in 2 crops, 45%) as a white solid

출처 및 근거

ORD 기록
ord-a1262f8e117d4da398c21aec6611a8b4
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592395B2

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