Piperazine → 5-fluoro-1-methyl-2-piperazin-1-yl-1H-benzimidazole

HRID 2045822노트

반응식

HRID 2045822 반응식
Cl[C:2]1[N:6]([CH3:7])[C:5]2[CH:8]=[CH:9][C:10]([F:12])=[CH:11][C:4]=2[N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>C(O)CCC>[F:12][C:10]1[CH:9]=[CH:8][C:5]2[N:6]([CH3:7])[C:2]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:3][C:4]=2[CH:11]=1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 219858282-Chloro-5-fluoro-1-methyl-1H-benzimidazole

생성물 1

HCID 220282485-fluoro-1-methyl-2-piperazin-1-yl-1H-benzimidazole

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

0.7 g 2-chloro-5-fluoro-1-methyl-1H-benzimidazole and 1.3 g piperazine are suspended in 10 ml n-butanol and stirred for 48 hours at ambient temperature. The reaction mixture is evaporated to dryness and the product is purified by chromatography (aluminium oxide, methylene chloride/methanol 10/1). 0.73 g (V-8) are obtained in the form of a solid. 1H NMR (400 MHz, DMSO): 6.9 (1H, t); 3.6 (3H, s).

후처리

  1. customThe reaction mixture is evaporated to dryness
  2. customthe product is purified by chromatography (aluminium oxide, methylene chloride/methanol 10/1)
  3. custom0.73 g (V-8) are obtained in the form of a solid

출처 및 근거

ORD 기록
ord-375cc365f43f425b9116440d876f4d87
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592400B2

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