Sodium hydride → HCID 70654271, 화합물

HRID 2046195노트

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HRID 2046195 반응식
[O:1]([CH2:8][C:9]1[CH:18]=[C:12]2[C:13](=[O:17])[NH:14][CH2:15][CH2:16][N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:20][CH:21]([CH3:40])[O:22][Si:23]([C:36]([CH3:39])([CH3:38])[CH3:37])([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[H-].[Na+]>C1COCC1>[C:36]([Si:23]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[O:22][CH:21]([CH3:40])[CH2:20][N:14]1[CH2:15][CH2:16][N:11]2[N:10]=[C:9]([CH2:8][O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:18]=[C:12]2[C:13]1=[O:17])([CH3:38])([CH3:39])[CH3:37]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 20770385HCID 20770385, 화합물HCID 574117992-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

생성물 1

HCID 70654271HCID 70654271, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
150 °C

실험 절차

2-Phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one (60 mg, 0.25 mmol) was added to a suspension of (rac)-(2-bromo-1-methyl-ethoxy)-tert-butyl-diphenyl-silane (0.23 g, 0.62 mmol) and 60% dispersion of sodium hydride in mineral oils (11 mg, 0.29 mmol) in THF (2 mL) at 0° C. The mixture was allowed to reach room temperature and stirred at 150° C. for 15 minutes under microwave irradiation. The mixture was used as such in the next step.

후처리

  1. customto reach room temperature

출처 및 근거

ORD 기록
ord-63863b38cd3b40b5b6e8a241a8e0a768
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592422B2

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