Hydrochloric Acid → 7-Amino-5-morpholino-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile

HRID 2047161노트

반응식

HRID 2047161 반응식
C[Si](C)(C)CCOC[N:7](COCC[Si](C)(C)C)[C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]4[C:25]([CH:26]=3)=[CH:24][CH:23]=[CH:22][CH:21]=4)=[C:12]2[N:11]=[C:10]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[C:9]=1[C:33]#[N:34].Cl>CCO>[NH2:7][C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]3[CH:18]=[N:19][C:20]4[C:25]([CH:26]=3)=[CH:24][CH:23]=[CH:22][CH:21]=4)=[C:12]2[N:11]=[C:10]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)[C:9]=1[C:33]#[N:34]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67494439HCID 67494439, 화합물

생성물 1

HCID 581733007-Amino-5-morpholino-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of 7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-5-morpholino-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidine-6-carbonitrile (5 mg), EtOH (1 mL) and 3N HCl (1 mL) was heated at 60° C. until LCMS indicated the completed reaction. The mixture was cooled to room temperature and the solvent was evaporated in vacuo. Purification by prep-LC afforded the desired compound. LCMS tR=3.12 Min (UV254nm). Mass calculated for, M+ 371.1, observed LC/MS m/z 372.2 (M+H).

후처리

  1. customthe completed reaction
  2. temperatureThe mixture was cooled to room temperature
  3. customthe solvent was evaporated in vacuo
  4. customPurification

출처 및 근거

ORD 기록
ord-a1250c9cfa9a49328077e774ded415a1
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08591943B2

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