Sodium borohydride → 1-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-ol

HRID 2047381

반응식

HRID 2047381 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[C:12]([N:17]2[CH2:22][CH2:21][C:20](=[O:23])[CH2:19][CH2:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16].[BH4-].[Na+]>CO>[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[CH:11]=[C:12]([N:17]2[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 595682431-[3-(1H-benzo[d]imidazol-2-yl)-4-chlorophenyl]piperidin-4-one

생성물 1

HCID 595683691-[3-(1H-Benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-ol수율 36%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of 1-[3-(1H-benzoimidazol-2-yl)-4-chloro-phenyl]-piperidin-4-one (0.05 g, 0.17 mmol) in methanol (50 mL) was added sodium borohydride (NaBH4) (0.01 g, 0.17 mmol) and the resulting mixture was stirred for 1 h at room temperature and then quenched with few drops of water. The solvent was removed under reduced pressure, the crude dissolved in EtOAc (5 mL) and filtered, then the organic phase was evaporated under reduced pressure to afford 0.02 g (36%) of the title compound.

후처리

  1. customquenched with few drops of water
  2. customThe solvent was removed under reduced pressure
  3. dissolutionthe crude dissolved in EtOAc (5 mL)
  4. filtrationfiltered
  5. customthe organic phase was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b68508f9a2104c64b457a0df3cd08835
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592463B2

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