2-(2-Chloro-5-[1,4]diazepan-1-yl-phenyl)-1H-benzoimidazole (0.25 g, 0.76 mmol), HOBt (0.12 g, 0.86 mmol), NMM (0.5 mL, 3.9 mmol), piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (0.17 g, 0.76 mmol), and EDC (0.22 g, 1.16 mmol) were dissolved in DCM (8.0 mL) and stirred at 20° C. for 16 h. Water (6.0 mL) was added. Organic layer was separated, concentrated under reduced pressure and crude was purified by flash chromatography (eluent: 100% of AcOEt) to afford 0.25 g of the title compound. (100%).
