[C:1]([NH:4][NH2:5])([NH2:3])=[NH:2].Cl.[OH-].[Na+].[CH2:9]([CH:11]([C:15](=O)[CH3:16])[C:12](=O)[CH3:13])[CH3:10]>O>[CH2:9]([C:11]1[C:15]([CH3:16])=[N:2][C:1]([N:4]2[C:12]([CH3:13])=[C:11]([CH2:15][CH3:16])[C:9]([CH3:10])=[N:5]2)=[N:3][C:12]=1[CH3:13])[CH3:10]To aminoguanidine hydrochloride (1.76 g, 15.9 mmol), water (5 ml), sodium hydroxide (636 mg, 15.9 mmol), and 3-ethyl-2,4-pentanedione (manufactured by Tokyo Chemical Industry, purity: 90.0% or higher) (4.50 g, 35.0 mmol) were added, and then stirred at 80° C. for 8 hours. To the reaction mixture, water (30 ml) was added, and then stirred at 0° C. for 1 hour. The precipitated crystals were collected by filtration, washed with water, and dried under reduced pressure to obtain 5-ethyl-2-(4-ethyl-3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine (1.35 g, 33%).
불러오는 중…
