Hydrochloric Acid → Ethyl 2,2-dimethylbutanoate

HRID 2047642노트

반응식

HRID 2047642 반응식
Cl.[CH3:2][C:3]([CH3:9])([CH2:7][CH3:8])[C:4]([OH:6])=[O:5].O.[CH2:11](O)[CH3:12]>>[CH2:11]([O:5][C:4](=[O:6])[C:3]([CH3:9])([CH3:2])[CH2:7][CH3:8])[CH3:12]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 962WaterHCID 116842,2-Dimethylbutanoic acid

생성물 1

HCID 12647075Ethyl 2,2-dimethylbutanoate

실험 절차

Add 0.2 mL of concentrated hydrochloric acid to 2,2-dimethyl-butanoic acid (5.0 g, 43.0 mmol) in ethanol (43 mL) and heat to reflux for 5 hours. Cool to room temperature. Pour the reaction into water and extract with diethyl ether. Wash the combined organics with saturated aqueous sodium bicarbonate and water, dry over magnesium sulfate, filter, and concentrate under reduced pressure to afford the title compound which was used without further purification (4.0 g, 64.4%): 1H NMR (CDCl3) δ 0.82 (t, 3H, 1.14 (s, 3H), 1.23 (t, 3H), 1.55 (q, 2H), 4.1 (q, 2H).

후처리

  1. temperatureheat
  2. temperatureto reflux for 5 hours
  3. additionPour
  4. extractionextract with diethyl ether
  5. washWash the combined organics with saturated aqueous sodium bicarbonate and water
  6. dry with materialdry over magnesium sulfate
  7. filtrationfilter
  8. concentrationconcentrate under reduced pressure

출처 및 근거

ORD 기록
ord-59e87af6c13d4a4197ab5e5aa2efb6b9
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592590B2

반응 노트

불러오는 중…