Phosphorus oxychloride → Ethyl 4-chloro-6-propoxyquinoline-3-carboxylate

HRID 2047734

반응식

HRID 2047734 반응식
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH2:13][CH2:14][CH3:15])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17].O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH2:13][CH2:14][CH3:15])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178458202Ethyl 4-hydroxy-6-propoxyquinoline-3-carboxylate

생성물 1

HCID 62328167Ethyl 4-chloro-6-propoxyquinoline-3-carboxylate

실험 절차

Prepared as in Example 1b from ethyl 4-hydroxy-6-propoxyquinoline-3-carboxylate (Example 14c) and POCl3 as a pale yellow solid. MS 294, 296 (MH+).

출처 및 근거

ORD 기록
ord-45412097eada4aadb3eee89cf6094bf2
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592592B2

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