Hydrazine hydrate (1:1) → 1H-pyrrole-2-carbohydrazonamide

HRID 2048131노트

반응식

HRID 2048131 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].O.[NH2:12][NH2:13]>C(O)C.O>[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:12][NH2:13])[NH2:7]

참가 물질

6

반응물 3

HCID 24654Hydrazine hydrate (1:1)HCID 138277Pyrrole-2-carbonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 1363872481H-pyrrole-2-carbohydrazonamide

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 1H-pyrrole-2-carbonitrile 10 g (108 mM) and sodium methoxide (1 eq) in ethanol (20 ml) and stirred for 10 min. Hydrazine hydrate (3 eq.) is then added and resulting reaction mixture is stirred at room temperature for 18 hrs. Reaction mass is then diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulphate and concentrated under vacuum to yield desired compound.

후처리

  1. customresulting
  2. customreaction mixture
  3. customReaction mass
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over anhydrous sodium sulphate
  6. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-b2f4fdbed86e461184fdb9e306592e34
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592591B2

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