Methyl iodide → 1-(m-Chlorophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane hydrochloride

반응식

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:14][CH:13]2[CH2:12][NH:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.[CH3:15]I>>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:14][CH:13]2[CH2:12][N:11]([CH3:15])[CH2:10]3)[CH:6]=[CH:7][CH:8]=1

참가 물질

반응물 2

HCID 6328Methyl iodide

HCID 127198451-(3-Chlorophenyl)-3-azabicyclo[3.1.0]hexane Hydrochloride

생성물 1

HCID 128913621-(m-Chlorophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane hydrochloride

실험 절차

By the method of Example 10, 1-(m-chlorophenyl)-N-methyl-1,2-cyclopropanedicarboximide, m.p. 72°-73° C., prepared from 1-(m-chlorophenyl)-1,2-cyclopropanedicarboximide (Example 6) and methyl iodide gives 1-(m-chlorophenyl)-3-methyl-3-azabicyclo[3.1.0]hexane hydrochloride as colorless crystals, m.p. 180°-182° C.

출처 및 근거

ORD 기록: ord-68588d08e6344b5789ad17d3f48614e4
출처 데이터셋: uspto-grants-1980_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04196120

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