Ethanone, 2-chloro-1,2-diphenyl- → Thiazole, triphenyl-

HRID 2049272

반응식

HRID 2049272 반응식
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]1([C:16]([CH:18](Cl)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(O)(C)C>[C:10]1([C:16]2[S:8][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:9][C:18]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 95343Ethanone, 2-chloro-1,2-diphenyl-HCID 683563Thiobenzamide

생성물 1

HCID 1712256Thiazole, triphenyl-

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Thiobenzamide (13.7 g, 0.10 mole) and desyl chloride (23.1 g, 0.10 mole) are heated under reflux in isopropyl alcohol (100 ml) for three hours. When the reaction mixture is cooled, the white solid precipitate formed is filtered off, washed twice with isopropyl alcohol, and dried. The yield of triphenylthiazole, m.p. 84°-85.5° C., is 21.5 g or 69%.

후처리

  1. temperatureWhen the reaction mixture is cooled
  2. customthe white solid precipitate formed
  3. filtrationis filtered off
  4. washwashed twice with isopropyl alcohol
  5. customdried

출처 및 근거

ORD 기록
ord-3912ad2349f94687be5fa180fdf6869a
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04197306

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