Hydrochloric Acid → 4-(Chloromethyl)benzophenone

HRID 2049904

반응식

HRID 2049904 반응식
C[C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].ClCl.[ClH:18].[CH:19](O)(C)C>>[Cl:18][CH2:19][C:14]1[CH:15]=[CH:2][C:3]([C:4]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)=[O:5])=[CH:12][CH:13]=1

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 24526Chlorine2회HCID 672302-Methylbenzophenone

생성물 1

HCID 30163764-(Chloromethyl)benzophenone수율 57%

실험 절차

The amount of 912 grams (4.65 moles) of methyl benzophenone was then melted and heated to 100°-110° C. in a two-liter, two-necked, round bottom flask with magnetic stirring. Chlorine gas was introduced through a gas dispersion tube immersed below the liquid at a rate such that the characteristic greenish color of chlorine was not detectable in the exiting stream of hydrogen chloride. Initially the reaction was exothermic and no additional external heating was required. After about seven hours the theoretical uptake in weight (160 g) had occured. The hot melt was poured into 6 liters of isopropyl alcohol. This mixture was chilled to -5° to 0° C. and the precipitated solid was removed by suction filtration to provide 618 grams (57% yield) of 4-(chloromethyl)benzophenone, mp 109°-111° C. A carbonyl band at 1670 cm-1 was noted in the infrared spectrum.

후처리

  1. temperatureheated to 100°-110° C. in a two-liter
  2. temperatureno additional external heating
  3. temperatureThis mixture was chilled to -5° to 0° C.
  4. customthe precipitated solid was removed by suction filtration

출처 및 근거

ORD 기록
ord-dde9ee2b13594739af835b2403a2a649
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04199420

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