Potassium Carbonate → [1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide

HRID 2050

반응식

HRID 2050 반응식
[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[N:8]([CH2:16][CH2:17][CH2:18][CH3:19])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].Cl[CH2:21][P:22](=[O:25])([CH3:24])[CH3:23].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[N:12]([CH2:21][P:22](=[O:25])([CH3:24])[CH3:23])[CH:11]=[N:10][C:9]=2[N:8]([CH2:16][CH2:17][CH2:18][CH3:19])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 1014211,3-Dibutylxanthine

생성물 1

HCID 19689263[1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5 g (0.01 9 mol) of 1,3-dibutylxanthine were stirred at 80° C. for 6 hours with 2.88 g (0.0228 mol) of chloromethyldimethylphosphine oxide and 3.2 g (0.0228 mol) of potassium carbonate in 80 ml of DMF. The solution was cooled to room temperature and filtered, and the filtrate was concentrated under reduced pressure. The residue which remained was crystallized in petroleum ether/ethyl acetate.

후처리

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue which remained was crystallized in petroleum ether/ethyl acetate

출처 및 근거

ORD 기록
ord-20ece88fc4e64225b2c8a9f117afb490
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728686

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