Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → cis-3-Amino-2-azidomethyl-4-oxoazetidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine | HCID 86734331 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | cis-3-Amino-2-azidomethyl-4-oxoazetidine | HCID 86734332 | — |
반응 단계
cis-2-Azidomethyl-3-t-butoxycarbonylamino-4-oxoazetidine (ca. 1 g) is dissolved in 2 ml of methylene chloride and the solution is cooled to 0° and treated with 0.5 ml of trifluoroacetic acid for 30 minutes at 0°. The solution is washed with 5% aqueous sodium bicarbonate and extracted with dilute hydrochloric acid. The aqueous phase is neutralized and extracted with ethyl acetate. Evaporation of the solvent gives the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04200572 |
| 출처 데이터셋 | uspto-grants-1980_04 |
| ORD ID | ord-3611998dda704930ba5869cca4bd70f6 |
| 출처 메모 | uspto-grants-1980_04 |