Benzyl Bromide → HCID 20058376, 화합물

HRID 2050514

반응식

HRID 2050514 반응식
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]([C:9]2[N:19]3[C:20]4[N:12]([C:13](=[O:22])[NH:14][C:15](=[O:21])[C:16]=4[CH:17]=[N:18]3)[CH2:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[H-].[Na+].[CH2:27](Br)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CN(C)C=O>[C:28]1([CH2:27][N:14]2[C:13](=[O:22])[N:12]3[C:20]4[N:19]([C:9]([C:5]5[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:23])[F:24])[CH:4]=5)=[CH:10][CH2:11]3)[N:18]=[CH:17][C:16]=4[C:15]2=[O:21])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 150440768-(3-(Trifluoromethyl)phenyl)-3H,6H-1,4,5a,8a-tetraazaacenaphthylene-3,5(4H)-dione

생성물 1

HCID 20058376HCID 20058376, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a stirred mixture of 4.0 g of 8-(3-(trifluoromethyl)phenyl)-3H,6H-1,4a,8a-tetraazaacenaphthylene3,5(4H)-dione (prepared as described in Example 14) in 40 ml of dry N,N-dimethylformamide, under nitrogen, is added 650 mg of 60 percent sodium hydride (dispersion in mineral oil). The mixture is stirred at room temperature for 2 hours, then 2.5 g of benzyl bromide is added and the mixture is stirred for 40 hours.

후처리

  1. stirringthe mixture is stirred for 40 hours

출처 및 근거

ORD 기록
ord-87673d208b61433f92c9ea4f2c86ea72
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05013737

연결된 노트

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