Acetone → 2,2-Dimethyl-4-oxo-3,4-dihydro-2H-1-benzopyran-6-carbonitrile

HRID 2050654노트

반응식

HRID 2050654 반응식
[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[OH:12])[C:7]#[N:8])(=[O:3])[CH3:2].[CH3:13][C:14]([CH3:16])=O.N1CCCC1.C1(C)C=CC=CC=1>O>[CH3:13][C:14]1([CH3:16])[CH2:2][C:1](=[O:3])[C:4]2[C:11](=[CH:10][CH:9]=[C:6]([C:7]#[N:8])[CH:5]=2)[O:12]1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 1140TolueneHCID 31268PyrrolidineHCID 123328323-Acetyl-4-hydroxybenzonitrile

생성물 1

HCID 109545982,2-Dimethyl-4-oxo-3,4-dihydro-2H-1-benzopyran-6-carbonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 81 g of 3-acetyl-4-hydroxybenzonitrile, 48 ml of acetone, 11.8 ml of pyrrolidine and 300 ml of toluene is allowed to stand at 20° for 1 hour, then boiled for 2 hours in a water separator and cooled. After customary working up, 2,2-dimethyl-6-cyano-4-chromanone is obtained, m.p. 119°-120°.

후처리

  1. temperaturecooled

출처 및 근거

ORD 기록
ord-76752389c9224028936bdf15e31aaf87
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05013853

반응 노트

불러오는 중…