Ammonia → 2-Bromoimidazo[1,2-a]pyridine

HRID 2051111노트

반응식

HRID 2051111 반응식
P(Br)(Br)([Br:3])=O.O[C:7]1[N:8]=[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]2[CH:15]=1.N>>[Br:3][C:7]1[N:8]=[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]2[CH:15]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 24613Phosphorus oxybromideHCID 14674030Imidazo[1,2-a]pyridin-2-ol

생성물 1

HCID 124289572-Bromoimidazo[1,2-a]pyridine수율 19.9%

반응 조건

온도
90 °C

실험 절차

To 44.0 g of melted phosphorus oxybromide, 12.0 g of 2-hydroxyimidazo[1,2-a]pyridine is added at 60°-85° C. and stirred for 3 hours at 90° C. The mixture is poured into 300 ml of ice water, neutralized with aqueous ammonia and then extracted with chloroform. The collected chloroform layer is dried over anhydrous sodium sulfate. Chloroform is distilled off and the residue is purified by silica gel chromatography (eluent: chloroform) to obtain 3.5 g of the title compound as a crystalline solid.

후처리

  1. extractionextracted with chloroform
  2. dry with materialThe collected chloroform layer is dried over anhydrous sodium sulfate
  3. distillationChloroform is distilled off
  4. customthe residue is purified by silica gel chromatography (eluent: chloroform)

출처 및 근거

ORD 기록
ord-3b91fc7bc6524740bf49fea0aaeb9b01
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05017212

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