Hydrochloric Acid → 2-Methylpyrazolo[1,5-a]pyrimidine

HRID 2051118노트

반응식

[NH2:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.CO[CH:10](OC)[CH2:11][CH:12](OC)OC.Cl>>[CH3:7][C:5]1[CH:6]=[C:2]2[N:1]=[CH:10][CH:11]=[CH:12][N:3]2[N:4]=1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 66019Tetramethoxypropane

HCID 931461H-Pyrazol-3-amine, 5-methyl-

생성물 1

HCID 127735592-Methylpyrazolo[1,5-a]pyrimidine

실험 절차

3-Amino-5-methylpyrazole is reacted with 1,1,3,3-tetramethoxypropane under an acidic condition of hydrochloric acid and treated in a similar way to Reference Example 22 to give the title compound as a crystal. mp. 54°-57° C.

후처리

additiontreated in a similar way to Reference Example 22

출처 및 근거

ORD 기록: ord-ff69ca68fa9141ce992684b025a678e4
출처 데이터셋: uspto-grants-1991_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05017212

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