Water → 1-Methyl-α-[3-(trifluoromethyl)phenyl]-1H-imidazole-2-methanol
반응식
[BH4-].[Na+].[CH3:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1)=[O:10].O>CO>[CH3:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[CH:12]=1)[OH:10]참가 물질
5
실험 절차
0.6 g of sodium borohydride is added to a solution of 3.6 g of 1-methyl-α-(3-trifluoromethylphenyl) -1H-imidazole-2-methanone in 25 ml of methanol. The mixture is stirred for 30 minutes and 150 ml of water are added. The precipitate obtained is filtered off and washed with water. It is recrystallized from an ethanol/water mixture.
후처리
- customThe precipitate obtained
- filtrationis filtered off
- washwashed with water
- customIt is recrystallized from an ethanol/water mixture
출처 및 근거
- ORD 기록
- ord-8c8c3e1d502b46fbbe9426a89420b007
- 출처 데이터셋
- uspto-grants-1991_05
- 특허 번호
- US05017596
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