Sodium Hydroxide → N-[2-(4-acetamidobutyryl)-5-chlorohydrocinnamoyl]glycine
반응식
[OH-].[Na+].[C:3]([NH:6][CH2:7][CH2:8][CH2:9][C:10]([C:12]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:13]=1[CH2:14][CH2:15][C:16]([NH:18][CH2:19][C:20]([O:22]CC)=[O:21])=[O:17])=[O:11])(=[O:5])[CH3:4]>O1CCCC1>[C:3]([NH:6][CH2:7][CH2:8][CH2:9][C:10]([C:12]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][C:13]=1[CH2:14][CH2:15][C:16]([NH:18][CH2:19][C:20]([OH:22])=[O:21])=[O:17])=[O:11])(=[O:5])[CH3:4]참가 물질
4
실험 절차
15 ml of 2N sodium hydroxide solution are added to a solution of 1.50 g (0.004 mol) of ethyl N-[2-(4-acetamidobutyryl) -5-chlorohydrocinnamoyl]glycinate in 15 ml of tetrahydrofuran and the mixture is stirred at room temperature for 1 hour. After acidification with 17 ml of 2N hydrochloric acid, the mixture is extracted with ethyl acetate/water, dried with magnesium sulfate and the solvent is distilled in a vacuum. Recrystallization from ethyl acetate/ether yields N-[2-(4-acetamidobutyryl) -5-chlorohydrocinnamoyl]glycine as white crystals with melting point 88-89°.