[C:1]([NH:6][C:7]1[CH:12]=[CH:11][C:10](Br)=[CH:9][N:8]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].[C:14]1(C)C=CC=C[C:15]=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.C(N(CC)CC)C.C=C>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C(#N)C>[C:1]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([CH:14]=[CH2:15])=[CH:9][N:8]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3]
A mixture of 9.72 g of 2 isobutyramido-5-bromopyridine, 0.49 g of tris-(0-tolyl)phosphine, 110 mg of palladium acetate, 10 ml of triethylamine and 30 ml of acetonitrile was heated at 80° C. in a glass lined vessel at 200 psi of ethylene for 18 hours. The reaction mixture was concentrated under reduced pressure and the residue chromatographed on el (0-25% ethyl acetate/methylene chloride) to give 6.67 g of pure product, m.p. 77°-8° C.; Analysis: Calc'd for C11H14N2O:
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