Water → cis-Octahydroisoindole

HRID 2051613

반응식

HRID 2051613 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]1(=O)[NH:11][C:10](=O)[C@H:9]2[CH2:13][CH2:14][CH2:15][CH2:16][C@@H:8]12.O>C(OCC)C.O1CCCC1>[C@@H:8]12[CH2:7][NH:11][CH2:10][C@@H:9]1[CH2:13][CH2:14][CH2:15][CH2:16]2

참가 물질

6

반응물 3

HCID 962WaterHCID 6992236cis-HexahydrophthalimideHCID 21226445Aluminium lithium hydride

생성물 1

HCID 10964494cis-Octahydroisoindole

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

To a slurry of lithium aluminium hydride (17.1 g) in dry diethyl ether (375 ml) under a nitrogen atmosphere, cis-hexahydrophthalimide (23.0 g) in dry tetrahydrofuran (300 ml) was added over a two-hour period. The mixture was refluxed for 2.5 hours, cooled and treated very slowly with excess of water. The precipitate was filtered off and the filtrate was evaporated to yield the title compound as a viscous oil, which was used in the next step without purification.

후처리

  1. temperatureThe mixture was refluxed for 2.5 hours
  2. temperaturecooled
  3. filtrationThe precipitate was filtered off
  4. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-d5fdc02a68d7413188ac41fca4b5cb6f
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04181659

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