Sodium Hydroxide → Diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate

HRID 2051754노트

반응식

HRID 2051754 반응식
[OH-].[Na+].[C:3]([C:8]1[CH:28]=[CH:27][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])=[CH:10][CH:9]=1)([O:5]CC)=[O:4]>C(O)C>[C:3]([C:8]1[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])=[CH:27][CH:28]=1)([OH:5])=[O:4]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 5271409Benzoic acid, 4-((6-(diethoxyphosphinyl)hexyl)oxy)-, ethyl ester

생성물 1

HCID 5271411Diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate수율 90.9%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution (21 ml) of 1N sodium hydroxide in ethanol was added to a solution of 8.3 g of diethyl [6-(4-carbethoxyphenoxy)hexyl]phosphonate (Example 8) in 20 ml of ethanol. The reaction mixture was stirred at room temperature for two days. The solid fraction was collected, digested with 100 ml of ether, filtered and dried to give 7.0 g of diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate in the form of its sodium salt, m.p. 215°-216° C.

후처리

  1. customThe solid fraction was collected
  2. filtrationfiltered
  3. customdried

출처 및 근거

ORD 기록
ord-e1086161db3d4d7494d7ca12ff7fbd34
출처 데이터셋
uspto-grants-1980_01
특허 번호
US04182759

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